The non-hormonal pill was 99% effective at preventing pregnancy in mice, new research found.
to get there. Most of these proposed options work by targeting testosterone, which could come with unwanted side effects like higher cholesterol or lower sex drive. The UMN team thinks their treatment could skate past these concerns, which could make it a more appealing option, according to lead researcher Md Abdullah Al Noman, a graduate student in medicinal chemistry at the university.
“Since men do not have to suffer the consequences of pregnancy, the threshold for side effects from birth control pills is rather low,” Noman told Gizmodo in an email. “That’s why we’re trying to develop nonhormonal birth control pills to avoid hormonal side effects.” So far, the compound—dubbed GPHR-529—seems to work as intended. In new data presented Wednesday at the spring meeting of the American Chemical Society, the team found that male mice dosed with the treatment for four weeks consistently experienced a sharp drop in sperm count and became sterile. Overall, GPHR-529 was estimated to be 99% effective in preventing pregnancy, with no noticeable side effects. And about four to six weeks after they stopped taking it, the male mice were no longer sterile.
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