A study published in Respiratory Research finds that blood miRNA classifier improves the early prediction of fatal outcomes in critically ill COVID-19 patients. Potential miRNA-based antiviral therapeutics warrant consideration.
]. Deidentified patient data were abstracted manually from the electronic medical records and stored in a Research Electronic Data Capture database hosted in the Centro de Investigación Biomédica en Red . Data from patients’ medical records were incorporated into the database by trained local researchers. The study coordinators ensured the integrity and timely completion of data collection.
The study protocol was approved by the respective ethics committee of each participating hospital. The study was designed and conducted in compliance with the Declaration of Helsinki and national and international law on data protection. Participants, or their legal representatives, provided informed consent, when possible, for the use of the samples and data. In the remaining cases, an informed consent waiver was authorized by the ethics committee.
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Effects of corrective and breathing exercises on respiratory function of older adults with a history of COVID-19 infection: a randomized controlled trial - BMC Complementary Medicine and TherapiesBackground Patients with a history of COVID-19 infection may suffer from different physical problems. This study aimed to investigate the effect of corrective and breathing exercises on improving respiratory function among patients with a history of COVID-19 infection. Methods In this clinical trial study, thirty elderlies with a history of COVID-19 disease were divided into two groups (mean age 63.60 ± 3.56 experimental, 59.87 ± 2.99 control groups) based on the study inclusion criteria. Exercise interventions included two sections- breathing exercises and corrective exercises in the cervical and thoracic spine. The spirometry test, craniovertebral angle, and thoracic kyphosis test were used. To evaluate differences between variables, paired-samples t-test and ANCOVA were used (p-value 0.01). The Eta-squared value of 0.51 for the Craniovertebral angle and the SPO2 indicates a large effect size. Conclusions The results showed the combination of corrective and breathing exercises could improve pulmonary function and correct cervical and thoracic posture in patients with a history of COVID-19 infection. Therefore, corrective and breathing exercises can be helpful as a complementary treatment along with pharmaceutical therapy to reduce chronic pulmonary complications in patients infected with COVID-19. Trial registration This research was registered in the Iranian Registry of Clinical Trials (IRCT registration number: IRCT20160815029373N7, First trial registration: 23/08/2021, Registration date: 01/09/2021).
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