A new study run by Duke University biologists and published Tuesday in the journal Cell Stem Cell gets us one step closer to understanding regeneration by copying and pasting DNA from a fish into mouse and pig hearts.
When we admire a creature like a lizard, starfish, or worm that can regenerate body parts after an injury, we’re really marveling at two qualities: these animals’ ability to regrow, and to stop regrowing. Because, in fact, a high degree of genetic precision is required to taper off growth signals that, when left unchecked,Scientists are fixated on this tightrope of regulated growth to one day help humans heal from heart attacks and other life-threatening injuries.
The Duke team edited the genetic code of mice and pigs to introduce those zebrafish enhancers, then created injuries by amputating digits, fracturing bones, or injecting a toxic compound into their skeletal muscle. When injected before the time of injury or slightly after, the zebrafish enhancers got to work, changing the kinds and amount of proteins that the animals made.
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