A new nonhormonal option for menopausal hot flashes: What prescribers should know
of data presented at ACOG's 2023 annual meeting noted fezolinetant's effectiveness among diverse populations, including White or Black race, BMI of 30 or higher, those younger or older than age 55, smokers, former smokers, and never smokers, in US as well as in European trial participants.confirmed safety for this time period. Adverse effects on the endometrium were neither seen nor expected, as fezolinetant is a centrally acting non–estrogen-containing medication.
Prior trials of neurokinin receptor antagonists suggested the potential for hepatotoxicity. Increases in ALT or AST noted in one of theof fezolinetant were described as asymptomatic, isolated, intermittent, or transient and returned to baseline during treatment or after discontinuation. However, the FDA placed a warning about liver injury potential. Package labeling recommends baseline liver function tests before starting fezolinetant and at 3, 6, and 9 months.
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