A link between hypoxia and fetal hemoglobin provides hope for sicklecelldisease nature
The authors thank K. A. Laycock for scientific editing of the manuscript; J. Olson, M. Babu, H. F. Bunn and H. Broxmeyer for discussions and comments on the manuscript; R. Kurita and Y. Nakamura for HUDEP-2 cells; D. Root for generating the CRISPR–Cas9 sgRNA library targeting components of the ubiquitin–proteasome system; G. Newby and D. R. Liu for the Lenti-ABE8-NG blasticidin vector; S. Henikoff for the protein A–micrococcal nuclease; and X.
Ruopeng Feng, Thiyagaraj Mayuranathan, Phillip A. Doerfler, Yichao Li, Yu Yao, Jingjing Zhang, Lance E. Palmer, Kalin Mayberry, Georgios E. Christakopoulos, Peng Xu, Yong Cheng & Mitchell J. WeissPeng Huang & Gerd A. BlobelChunliang Li Abramson Family Cancer Research Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA
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