A research team led by Prof. Chu Yannan at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences applied the untargeted analytical method of headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS) to detect volatile organic compounds (VOCs) in rat organs and obtained the biological information of VOCs metabolized by related organs.
The detection of VOCs in human metabolites has the potential to change the way we screen for and diagnose organ disease. It is expected to become a non-invasive method for identifying and monitoring disease in the body. However, whether VOCs are present in normal organs and whether there are differences in VOCs among different organs are still pressing issues to be explored.
In this study, the researchers analyzed and detected organs in a controlled laboratory setting using rats, which have a high genetic similarity to humans. Using HP-SPME-GC-MS technology, VOCs released from 12 organ tissues were measured, and chromatographic peaks were obtained. Based on the Mann Whitney U test and fold change, untargeted analysis revealed that seven organs showed differences in VOCs compared with other organs.
This study represents the first systematic report on the differential VOCs found in different organs of rats. The researchers extensively discussed the potential metabolic pathways of these VOCs and their possible role as biomarkers of disease.The results provide valuable insights for understanding organ-specific VOC profiles and their potential implications for disease diagnosis and monitoring.
In addition, by combining orthogonal partial least squares discriminant analysis with receiver operating characteristic curve , the researchers were able to validate the discriminative power of the differential VOCs in detecting each organ. This approach provides a reliable and accurate method for organ recognition based on VOC profiling, and the VOCs profiles of healthy organ tissues obtained in this study can serve as a baseline for scientific research, such as non-invasive screening and diagnosis of gas biopsy or breath test, disease treatment monitoring, and efficacy evaluation.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Advanced HF No Obstacle to AF Ablation Success: CASTLE-HTxThis 'should help eradicate the current somewhat nihilistic approach' to managing atrial fibrillation in advanced heart failure, said an expert.
Read more »
'Haunting in Venice' Gets Advanced Screenings With IMAX and Alamo DrafthouseThe film will be screened in select cities across the United States ahead of its wide release.
Read more »
MSNBC frets over Biden's advanced age: 'Even Democrats' worried about it, White House 'cannot avoid'MSNBC admitted that Biden's age was a serious concern that the White House needed to face, as a new poll shows even Democrats are worried about his age.
Read more »
Hackers shut down 2 of the world's most advanced telescopesIt's unclear exactly what the nature of the cyberattacks were or from where they originated.
Read more »
'Become Indian:' University of California Prof Who Claimed to Be Native American ResignsA prominent scholar and University of California, Riverside professor, who claimed to be Native American, has resigned after 13 faculty members accused her of false claims of Native identity that violated academic integrity. In an ironic twist, professor Andrea Smith once criticized white feminists for pretending to be Native Americans. She wrote, 'They do this by opting to 'become Indian.' In this way, they can escape responsibility and accountability for white racism.'
Read more »
China’s Debt Problem Could Trigger a Financial Crisis, Analyst SaysCharlene Chu, senior analyst at Autonomous Research, talks to Barron's about China’s ailing economy, high debt, troubled real-estate market, and opaque...
Read more »