Researchers found that participants with higher levels of exposure to air pollution in their 40s and 50s displayed worse cognitive functioning in verbal fluency from age 56 to 68.
Senior author William Kremen, professor of psychiatry and co-director of the Center for Behavior Genetics of Aging at the UCSD School of Medicine, and colleagues studied the men with a baseline age of 56, with 12 years of follow-up.
The genotype -- known as APOE -- has a version called APOE-4 that has been identified as a strong risk factor gene for Alzheimer's disease.
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