Alzheimer’s Drugs Advance but Slowing Disease Remains a Challenge

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Alzheimer’s Drugs Advance but Slowing Disease Remains a Challenge
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An experimental Alzheimer’s treatment successfully cleared plaque in the brain that has long thought to be a cause of the disease, but the benefit of such drugs for patients might have limits

Biogen’s Aduhelm is the first approved treatment for early-stage Alzheimer’s patients that may be able to slow the disease. WSJ explains how the drug interacts with brain cells, and why some doctors aren’t ready to prescribe it yet.

Illustration: Jacob ReynoldsStrong recent study results for an experimental Alzheimer’s treatment have exposed a gap between the changes such drugs can make in the brain and their potential limits in alleviating symptoms ofLecanemab cleared accumulations in the brain of beta-amyloid, sticky protein fragments that researchers have long suspected contribute to Alzheimer’s, drugmakers Biogen Inc. and Eisai Co. said last month.

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