The drug is already being tested on humans.
According to the National Cancer Institute, over 11,000 people in the U.S. could lose their life this year because of acute myeloid leukemia , a type of blood cancer resulting from the uncontrolled production of immature white blood cells in the bone marrow.
However, instead of keeping a check on cell division, menin has been found to be facilitating the mutations that lead to out-of-control cell multiplication in AML patients. This is where revumenib comes into play, this drug has the power to selectively inhibit menin., “Revuminib blocks a critical protein menin that has been previously shown to be necessary for the mutant proteins to keep AML cells alive and dividing.”During the first study, the researchers tested revumenib on 60 AML patients.
“In some leukemias that developed resistance to Revumenib, the MEN1 gene developed a mutation that decreased the binding power or activity of Revumenib. This shows that leukemia is highly dependent on Menin function and validates this therapeutic approach,” said Armstrong.The effectiveness of revumenib in inhibiting menin and the resistance further showed by theagainst this drug proves that it has the potential to give rise to an AML cure that will benefit millions of people across the globe.
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