Using some antidepressants during pregnancy may increase risk of gestational diabetes by 19%, a new study says.
Using any of these drugs increased the risk for gestational diabetes by 19%, compared with not taking them.The riskiest drugs were Effexor, which raised the risk 27%, and Endep, which increased it by 52%, the researchers found. The risk was greater the longer the drugs were taken and if more than one drug was prescribed.
Using the drugs for a short time increased the risk 15%, while taking them for a long time raised risk to 29%."The baseline prevalence of gestational diabetes is between 7% and 9%, hence a 15% increased risk would result in a prevalence of 10%, whereas a 52% increase would result in a 14% prevalence," she said."Hence, the increases remain small, but above what we would have expected.
It appears the SSRIs carry less risk than other antidepressants, Gupta said. But he believes that the first choice to fight depression during pregnancy should be non-pharmaceutical.But women who need these drugs should be taking them, Gupta said."Depression and the risk of depression may outweigh the risk of gestational diabetes," he said.SOURCES: Anick Berard, Ph.D., professor and research chair, medications, pregnancy and lactation, University of Montreal; Rahul Gupta, M.D., M.P.H.
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