A study in BMCGeriatr finds that intake of omega-3 polyunsaturated fatty acid is positively associated with sarcopenia outcomes whereas intake of omega-6 is negatively associated, in community-dwelling older adults.
Venous blood samples were collected by a phlebotomist. Samples were centrifuged immediately for 10 min at 1500 × g at 4 °C and RBC were separated from the blood sample. A solution of phosphate buffered solution, containing 1.5 mg/mL ethylenediaminetetraacetic acid, was added to preserve RBC. Samples were stored at -80 °C until in batch analysis. RBC fatty acid composition was analysed by OmegaQuant , using gas chromatography with flame ionization detection [].
Two health-related QoL instruments were used, namely the Short Form - 36 Health Survey and the Sarcopenia Quality of Life questionnaire . SF-36 is a generic health-related QoL instrument that includes eight health domains: physical functioning, role limitations due to physical and emotional health, mental health, bodily pain, general health, vitality and social functioning [].
]. Subjects were instructed to wear this device on five consecutive days prior to baseline visit. If worn less, data were excluded from the analysis. Total steps per day were calculated using the device software of the manufacturer.Descriptive statistics were used to summarize subjects’ baseline characteristics. Normality was checked through the Shapiro-Wilk test. Gender differences were evaluated through a two-sample t-test, with a-value < 0.05 considered significant.
A total of 29 community-dwelling older adults with probable, confirmed or severe sarcopenia were included. Baseline characteristics are described in Table. Mean age of the participants was 76.3 ± 5.4 years. According to EWGSOP2 criteria, 12 persons were categorized as having probable sarcopenia, 16 confirmed sarcopenia and one person was considered severely sarcopenic.
. Total energy intake was significantly higher in men compared to women . Furthermore, RBC %GLA was slightly higher in women compared to men . Otherwise, no other significant gender differences were found.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Petrobras To Appeal Amazon Oil Rejection In Lula Litmus Test | OilPrice.comBrazil’s state-run oil giant Petrobras is preparing to file a request to appeal a decision to reject the environmental license for exploratory drilling in the deep waters of the Amapa at the mouth of the Amazon
Read more »
CCTV captures moment Gay Village adult store Clonezone attacked for FOURTH timeA pair of masked thugs struck the glass door in what is the fourth attack in exactly two months
Read more »
Brief, weekly magnetic muscle therapy improves mobility and lean body mass in older adults: a Southeast Asia community case study | AgingAging | doi:10.18632/aging.204597. Sharanya Venugobal, Yee Kit Tai, Jorming Goh, Sean Teh, Craig Wong, Ivan Goh, Andrea B. Maier, Brian K. Kennedy, Alfredo Franco-Obregón
Read more »
The impact of metabolic endotoxaemia on the browning process in human adipocytes - BMC MedicineBackground Dysfunctional adipose tissue (AT) is known to contribute to the pathophysiology of metabolic disease, including type 2 diabetes mellitus (T2DM). This dysfunction may occur, in part, as a consequence of gut-derived endotoxaemia inducing changes in adipocyte mitochondrial function and reducing the proportion of BRITE (brown-in-white) adipocytes. Therefore, the present study investigated whether endotoxin (lipopolysaccharide; LPS) directly contributes to impaired human adipocyte mitochondrial function and browning in human adipocytes, and the relevant impact of obesity status pre and post bariatric surgery. Methods Human differentiated abdominal subcutaneous (AbdSc) adipocytes from participants with obesity and normal-weight participants were treated with endotoxin to assess in vitro changes in mitochondrial function and BRITE phenotype. Ex vivo human AbdSc AT from different groups of participants (normal-weight, obesity, pre- and 6 months post-bariatric surgery) were assessed for similar analyses including circulating endotoxin levels. Results Ex vivo AT analysis (lean & obese, weight loss post-bariatric surgery) identified that systemic endotoxin negatively correlated with BAT gene expression (p | 0.05). In vitro endotoxin treatment of AbdSc adipocytes (lean & obese) reduced mitochondrial dynamics (74.6% reduction; p | 0.0001), biogenesis (81.2% reduction; p | 0.0001) and the BRITE phenotype (93.8% reduction; p | 0.0001). Lean AbdSc adipocytes were more responsive to adrenergic signalling than obese AbdSc adipocytes; although endotoxin mitigated this response (92.6% reduction; p | 0.0001). Conclusions Taken together, these data suggest that systemic gut-derived endotoxaemia contributes to both individual adipocyte dysfunction and reduced browning capacity of the adipocyte cell population, exacerbating metabolic consequences. As bariatric surgery reduces endotoxin levels and is associated with improving adipocyte functionality, this may provide further evid
Read more »
Heart transplants from COVID-19 donors: Mixed outcomes revealed in early analysisIn a recent study published in the Journal of the American College of Cardiology, researchers investigated coronavirus disease 2019 (COVID-19)-infected donor use, donor and recipient characteristics, and early post-heart transplantation (HT) outcomes in the United States (US).
Read more »