Human genetic and mechanistic studies reveal thousands of pathogenic proteins that may serve as potential targets for small-molecule drugs. Meanwhile, the conventional method of drug discovery through inhibitors hinges on the 'druggability' of targets—a criterion determined by measurable biochemical activities and accessible binding sites.
Autophagy-tethering compounds may open new directions in targeted drug discovery retrieved 21 March 2024 from https://medicalxpress.com/news/2024-03-autophagy-tethering-compounds-drug-discovery.html
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