Patients are being urged not to switch practices despite the decision by Ballasalla Medical Centre.
A GP surgery in the south of the Isle of Man will hand back its contract to Manx Care in July.
The island's health body said while the news would "undoubtedly cause a lot of uncertainty" for patients, it would work with the practice to "secure the future provision of GP services".Manx Care said it would "consider all of the options available" so that patients can continue to be served by the practice in the future.
Local MKHs Jason Moorhouse and Tim Glover echoed calls by Manx Care not to switch GPs as the changes are six months away.
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