Bivalent COVID-19 booster vaccine shown to be highly effective in reducing deaths and hospitalizations TheLancetInfDis
The study assessed the Pfizer bivalent vaccine, since Pfizer is the main supplier of COVID vaccines to Israel. The study shows that, compared to people in this age group eligible to receive this bivalentyet who did not, those receiving it had a 72% lower risk of COVID-19 related hospitalization and a 68% lower risk of COVID-19 related death.
To date, randomized controlled trials evaluating the clinical efficacy of a bivalent mRNA booster vaccine are unavailable. The bivalent mRNA booster vaccines are currently prioritized in Israel for people at high risk of severe COVID-19, primarily those aged 65 years or older. This made it possible for the authors to do a retrospective cohort study to evaluate the effectiveness of a bivalent mRNA vaccine booster dose to prevent hospitalizations and deaths due to COVID-19.
The adjusted risk for COVID-19 hospitalizations in the bivalent mRNA booster recipients was 0.035% versus 0.124% in the non-recipients. Therefore the absolute risk reduction for hospitalizations due to COVID-19 was 0.089%, and accordingly, one hospitalization due to COVID-19 was avoided for every 1,118 people vaccinated.
The authors note some limitations of their study, including the low numbers of hospitalizations and deaths, and that use of only the Pfizer bivalent vaccine means that generalization of the results to other bivalent vaccines should be done with caution. Also, the study was not a direct comparison between bivalent and monovalent vaccines, since both were not administered at the same time in Israel during the study period.
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