Bivalent recombinant vaccine protects against SARS-CoV-2 and influenza in animal models umanitoba SARSCoV2 Influenza Vaccine Vaccination
By Tarun Sai LomteSep 15 2022Reviewed by Aimee Molineux In a recent study published in the Journal of Virology, researchers developed a recombinant bivalent vaccine against severe acute respiratory syndrome coronavirus 2 and influenza viruses.
Hence, designing a universal vaccine against all influenza strains is essential. Both influenza and COVID-19 are contagious diseases transmitted during the same seasons and pose a global threat to public health; as such, it is highly beneficial to design a vaccine that concurrently protects against SARS-CoV-2 and influenza viruses.
Two M2e copies were derived from human influenza strains, one from the avian flu strain and one from the swine flu strain. The replication ability of the candidate vaccines was examined in multiple cell lines such as A549, MRC-5, U251MG, cluster of differentiation 4-positive Jurkat T cells, and monocyte-derived macrophages and dendritic cells .
All candidates induced similarly high anti-M2 IgG and IgA antibodies regardless of the delivery route. Next, they evaluated neutralizing potency of antibodies induced by the vaccine candidates using SPΔC pseudoviruses. V-EM2e/ SPΔC1 vaccine induced the highest titers of neutralizing antibodies against SpΔCwildtype and SpΔCDelta pseudoviral infections, while V-EM2e/ERBD immunization had low neutralizing activity.
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