Brain-like organoids grown in a dish provide window into autism uofuhealthcare NatureComms
Neurons were hyperactive, firing more often in response to stimuli,Specific molecular pathways that cause cells to adhere to one another were disrupted.
"One goal is to use brain organoids to test drugs or other interventions to reverse or treat disorders," says Jan Kubanek, Ph.D., a co-author on the study and an assistant professor of biomedical engineering at the U. To create an improved model, Shcheglovitov's team took cues from how the brain develops normally. The researchers promptedto become neuroepithelial cells, a specific stem cell type that forms self-organized structures, called neural rosettes, in a dish.
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