Entrepreneur Bryan Johnson is attempting to circumvent death by meticulously controlling his lifestyle. But can diet and exercise truly slow aging like he claims, or are we genetically destined for our lifespans?
While healthy eating and regular workouts are certainly good for us, many scientists now believe that genes rather than lifestyle are the determining factor in how long we live
Skinny people don’t seem to live the longest. Overweight people live longer than their underweight, normal and obese peersa couple of extra years. Johnson, who is restricting his calories by 10%, is hoping it will work for him, too. But the restrictions in the animal studies are large and humans aren’t mice – or nematode worms.it’s difficult to verify that participants really maintained the restricted diets.
Newman believes this is why blue zones appear in poor, rural areas, places where there’s substandard record-keeping and pressure to commit pension fraud. In the UK, the relatively poor London borough of Tower Hamlets has thein the country, despite having a lower-than-average life expectancy overall. And longevity is linked to wealth – the countries in the world with the highest average life expectancy are rich ones.“The old-age suicide rate in Okinawa is the fourth highest in Japan.
A key driver of ageing is a process called cell senescence. Cells enter this toxic state as we age, damaging tissue and generating inflammation and disease. But Cox and colleaguesthat you can slow ageing if you manipulate these cells to behave as if they were younger. In 2009, ashowed the drug rapamycin could make mice live up to 14% longer.
“I’m very hesitant about the telomerase stuff because of the cancer risk, though some newer studies suggest it’s possible to minimise that risk,” says Cox.
Longevity Genetics Diet Exercise Aging
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