A genetic signature widely used to guide cancer treatments may not work for patients with African and Asian ancestries, according to a new study.
The finding could mean people with these backgrounds are receiving an expensive therapy that won’t help them and could even worsen their prognosis, scientists say.
. A few months later, the U.S. Food and Drug Administration approved the drug for the treatment of tumors with high TMB, which are found in some lung cancers, melanoma, and cervical cancer. A common algorithm used to compare disease and reference genomes also led to more false positives among people of non-European descent. Only 21% of patients of European ancestry had false high-TMB misclassifications, compared with 37% and 44% of patients of Asian or African descent, respectively, the team found.
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