It turns out that individuals who have been diagnosed with Cannabis Use Disorder are at greater risk of also developing depression and bipolar disorder
features . The anonymity of individuals was protected. Since all diagnoses were dated, Jefson could ask whether a diagnosis of CUD was associated with later affective diagnoses at a rate differing from the rate seen in individuals without CUD. Any increased rates were expressed as hazard ratios .
Individuals with CUD had a higher risk of unipolar depression compared with individuals with no record of a CUD. No significant difference existed in the hazard ratios of psychotic versus nonpsychotic depression.Most of these individuals were diagnosed with nonpsychotic bipolar disorder, while 9.8 percent were diagnosed with psychotic bipolar disorder. The hazard ratio of nonpsychotic bipolar disorder after a diagnosis of CUD was higher than for unipolar depression; 2.96 in men and 2.
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