In Brief: A clinical trial of chimeric antigen receptor-T cells in young people with high-risk neuroblastoma has afforded the best CAR-T cell responses seen to date in solid tumors
has afforded the best CAR-T cell responses seen to date in solid tumors. Out of 27 patients, 17 saw their tumors respond to CAR-T cells directed at the disialoganglioside GD2 in the trial, held at the Bambino Gesù Pediatric Hospital in Rome.
Nine of the 17 had a complete response and eight had a partial response. The three-year overall survival was 60%. “No one’s ever had patients responding like this before,” immunologist Carl June, not involved in the trial, was quoted as saying in an
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