Carbon Nanotubes: Advancing Biosensing for Infectious Diseases nanotubes infectiousdisease nanomaterials carbonnanomaterials CNTs
By Arzoo PuriMay 9 2023Reviewed by Megan Craig, M.Sc. The rising rate of infectious diseases with unidentified origins and ongoing mutations has emerged as a global threat. Identifying the microorganisms that cause these diseases rapidly and precisely is crucial, as doing so will allow for early disease diagnosis, transmission control, and therapy. This article focuses on employing carbon nanotubes for biosensing and imaging in infectious diseases.
Applying Nanomaterials to Biosensing and Imaging Current research aims to create novel nanomaterials with distinctive features for the advancement of detection methods. Carbon nanomaterials , in particular, have attracted immense interest in both material biomedical applications and science. Numerous recent studies have employed CNTs due to their excellent mechanical strength due to the presence of sp2 hybridized carbon atoms. Additionally, when the typical wall number is close to 2.7, CNTs exhibit promising electrical conductivity.
They developed F′-positive and F′-negative bacterial strain-distinguishing functionalized SWNTs, utilizing the M13 bacteriophage and an anti-bacterial antibody. The method is employed to identify intramuscular Staphylococcus aureus infections and to image S. aureus infective endocarditis. In another study, it was discovered that the gold nanoparticle and carbon nanotube nanocomposite had more catalytic activity than CNTs or AuNPs alone towards the oxidation of tetramethylbenzidine by hydrogen peroxide . The described nanocomposites have been employed in an immunosensor to detect the influenza A virus with sensitivity ≤ 10 PFU mL-1.
Several diagnostic techniques have been invented based on CNTs, including bioimaging contrast agents, nucleic-acid amplification tests enhancers to detect pathogenic genes and biosensors. These diagnostic technologies have a lot of potential, but a few issues still need to be resolved before they can be used in infectious disease diagnosis.
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