People often jokingly say they've 'got a bit of OCD' (obsessive-compulsive disorder) if they are overly organized or tidy.
While glutamate promotes communication between neurons, Gaba reduces or inhibits neural communication .
. Activity in the ACC changes in response to reward or punishment, guiding future decision-making. The SMA is involved in the coordination of motor sequences and seems to have a role in the production of habits. Importantly, the clinical severity of compulsive symptoms of OCD correlated with the glutamate levels we measured in the SMA. Self-rated questionnaires of compulsive tendencies by both people with OCD and those in a healthy volunteer control group also correlated with glutamate in this region.The finding raises hopes for better treatments for OCD, focusing on re-balancing glutamate and Gaba levels in key brain regions.
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