Researchers are gaining new insights into neurological diseases by studying circular RNAs (circRNAs) in brain cells. A new study has identified over 11,000 distinct RNA circles that characterized brain cells implicated in Parkinson's disease and Alzheimer's disease.
Researchers are gaining new insights into neurological diseases by studying circular RNAs in brain cells. A new study by investigators from the Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, identified over 11,000 distinct RNA circles that characterized brain cells implicated in Parkinson's disease and Alzheimer's disease.
They found that 61% of all synaptic circRNAs they characterized were associated with brain disorders. Notably, they found 4,834 cell-type specific circular RNAs in dopamine and pyramidal neurons, two highly functioning brain cells. Dopamine neurons control movement, mood, and motivation while pyramidal neurons play an important role in memory and language.
Degeneration of these dopamine and pyramidal neurons plays a key role in the development of neurological disorders. When researchers investigated this connection further, they found that a surprising number of Parkinson's and Alzheimer's genes produced circular RNA.
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