Analyses from the COMBI-i trial evaluating PD-1, BRAF and MEK inhibition in patients with metastatic melanoma demonstrate high response rates and uncover molecular correlates of long-term treatment benefit. Trial led by AACR23 speaker Reinhard Dummer
R.D. reports intermittent, project-focused consulting and/or advisory relationships with Novartis, Merck Sharp & Dohme , Bristol Myers Squibb , Roche, Amgen, Takeda, Pierre Fabre, Sun Pharma, Sanofi, Catalym, Second Genome, Regeneron and Alligator outside the submitted work. C.L.
Extended Data Fig. 2 Best percent change from baseline in sum of diameters by local investigator review . A total of 33 patients experienced a reduction in the size of the target lesion. One patient with SD had a best percent change of 0% in the target lesion. Best percent change in the target lesion was not available for 1 patient with PD. Best percent change in target lesion could not be calculated for 1 additional patient as best overall response was unknown. CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.
Extended Data Fig. 3 Time-to-event analyses, including DOR, PFS, and OS, in patients enrolled in parts 1 and 2 of COMBI-i . 12- and 24-month DOR rates were 80% and 53% ; 12- and 24-month PFS rates were 67% and 41% ; 12- and 24-month OS rates were 86% and 74% . DOR, duration of response; PFS, progression-free survival; NE, not estimable; OS, overall survival.Baseline T-cell–inflamed GES levels and TMB in samples from patients with and without a CR. For T-cell–inflamed GES: n=27 independent tumor biopsy specimens . For TMB: n=24 independent tumor biopsy specimens .
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