There are surprisingly little data on how to safely combine new targeted treatments for breast cancer alongside radiotherapy. Experts weigh in on what we know.
contributor and professor of oncology and medicine at the Indiana University School of Medicine, Indianapolis, Indiana.
Below is a guide to what we do and don't know about combining radiotherapy and systemic treatments in breast cancer.Safety data on combining immune checkpoint inhibitors and radiotherapy in breast cancer are limited because concurrent radiotherapy has typically been excluded in pivotal trials.trial did provide a rare look at concurrent radiotherapy and immunotherapy in early triple-negative breast cancer.
"These findings suggest that the simultaneous administration of CDK4/6 inhibitors and radiotherapy is generally well tolerated," the ESTRO authors concluded but added that CDK4/6 inhibitors and concomitant radiotherapy should be investigated more in the adjuvant locoregional, whole brain, and intracranial stereotactic radiotherapy settings.
Because of potential good or bad interactions between new systemic therapies and radiotherapy, "intentional trial design" is important, Jagsi said, so we "know the best way to combine treatments in practice to optimize outcomes." Clinical trial data on the safety of combining PI3K and mTOR inhibitors with radiation are thin, especially in advanced breast cancer. Typically, radiotherapy within 4 weeks before randomization, or 2 weeks for palliative radiation, was excluded in pivotal trials.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Oakland hospital helping kids recover by combining dogs and music therapyFor 11-year-old Jesus Roman Ramirez, everyday tasks can be a struggle battling Guillain-Barre Syndrome. But with the combination of music therapy and cuddles with Arnie at UCSF Benioff Children's Hospital, Jesus is healing mentally and physically.
Read more »
Batman & Spider-Man Clash in Genius Fanart Combining Their First Comic CoversAll the latest movie news, movie trailers & reviews - and the same for TV, too.
Read more »
Porsche Panamera: Combining Luxury and Sports Car PerformanceThe Porsche Panamera has always managed to combine luxury and sports car performance, putting it in a class of its own. With the introduction of the third generation, Porsche aims to keep the Panamera relevant with subtle styling changes and improved features. The top-spec Turbo models now offer a 'Turbonite' packaging option, while air suspension and 'Active Ride' setup enhance the driving experience. Despite its similarities to previous models, the Panamera offers more than meets the eye.
Read more »
Renewed push for aid for radiation victims of U.S. nuclear programSince 1990, the U.S. government has compensated some families with the Radiation Exposure Compensation Act, but the program's future is threatened by budget standoffs.
Read more »
Space tourism? Cosmic radiation exposureSpace weather experts are urging regulators and space tourism innovators to work together to protect their passengers and crews from the risks of space weather radiation exposure.
Read more »
Chernobyl worms appear unaffected by radiation from world's worst nuclear disasterJennifer Nalewicki is a Salt Lake City-based journalist whose work has been featured in The New York Times, Smithsonian Magazine, Scientific American, Popular Mechanics and more. She covers several science topics from planet Earth to paleontology and archaeology to health and culture. Prior to freelancing, Jennifer held an Editor role at Time Inc.
Read more »