Study identifies geneticmutations that contribute to adult epilepsy MassGenBrigham jamaneuro
Drs Khoshkhoo and Kahle had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Dr Khoshkhoo and Ms Wang are co–first authors. Drs E. Lee, Walsh, and Kahle are co–senior authors.Khoshkhoo, Wang, Stronge, Phillips, Scheffer, Lifton, Poduri, Walsh, Kahle.Khoshkhoo, Wang, Chahine, Robert, Kiziltug, Damisah, Kong, Chhouk, Adikari, N. Lee, Haider, Huttner, E. Lee, Walsh, Kahle.
Drs Khoshkhoo, Walsh, and Kahle have a patent for the causal role of Ras/Raf/MAPK pathway overactivation in focal epilepsy pending . Dr Stronge has received grants from National Institute of General Medical Sciences during the conduct of the study. Dr Phillips has received grants from the National Institute of Neurological Disorders and Stroke during the conduct of the study.
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Association between metabolic syndrome components and gingival bleeding is women-specific: a nested cross-sectional study - Journal of Translational MedicineBackground Metabolic syndrome (MetS) is a cluster of atherosclerotic risk factors that increases cardiovascular risk. MetS has been associated with periodontitis, but the contribution of single MetS components and any possible sexual dimorphism in this relation remain undetermined. Methods Using the third National Health and Nutrition Examination Survey (NHANES III), we performed a nested cross-sectional study to test whether individuals aged | 30 years undergoing periodontal evaluation (population) exposed to ≥ 1 MetS component (exposure) were at increased risk of bleeding/non-bleeding periodontal diseases (outcome) compared to nonexposed individuals, propensity score matched for sex, age, race/ethnicity, and income (controls). The association between MetS components combinations and periodontal diseases was explored overall and across subgroups by sex and smoking. Periodontal health status prediction based on MetS components was assessed. Results In total, 2258 individuals (n. 1129/group) with nested clinical-demographic features were analyzed. Exposure was associated with gingival bleeding (+ 18% risk for every unitary increase in MetS components, and triple risk when all five were combined), but not with stable periodontitis; the association was specific for women, but not for men, irrespective of smoking. The only MetS feature with significant association in men was high BP with periodontitis. CRP levels significantly increased from health to disease only among exposed women. MetS components did not substantially improve the prediction of bleeding/non-bleeding periodontal disease. Conclusion The observed women-specific association of gingival bleeding with single and combined MetS components advances gender and precision periodontology. Further research is needed to validate and expand these findings.
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Study finds little evidence of negative impact on mental health from increased home working during pandemicStudy finds little evidence of negative impact on mental health from increased home working during pandemic homeworking COVID19 mentalhealth socialwellbeing loneliness publichealth pandemicresearch workfromhome PLOSMedicine
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Study finds that improved access to mental health care is associated with reductions in suicide riskAmid historically high suicide rates and mental health care provider shortages, new research from Incite at Columbia University suggests that interventions to alleviate mental health care access disparities can prevent unnecessary death and suffering. In an article pending publication in Proceedings of the National Academy of Sciences next week, 'Differential Spatial-Social Accessiblity to Mental Health Care and Suicide,' Daniel Tadmon and Peter S. Bearman find that in the United States improved access to mental health care is associated with reductions in suicide risk.
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Finally, Some Exciting Progress For Finding The Root Cause Of EndometriosisThe news comes from the largest ever study on endometriosis
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Diabetes and anti-diabetic interventions and the risk of gynaecological and obstetric morbidity: an umbrella review of the literature - BMC MedicineBackground Diabetes has reached epidemic proportions in recent years with serious health ramifications. The aim of this study was to evaluate the strength and validity of associations between diabetes and anti-diabetic interventions and the risk of any type of gynaecological or obstetric conditions. Methods Design: Umbrella review of systematic reviews and meta-analyses. Data sources: PubMed, Medline, Embase, Cochrane Database of Systematic Reviews, manual screening of references. Eligibility criteria: Systematic reviews and meta-analyses of observational and interventional studies investigating the relationship between diabetes and anti-diabetic interventions with gynaecological or obstetric outcomes. Meta-analyses that did not include complete data from individual studies, such as relative risk, 95% confidence intervals, number of cases/controls, or total population were excluded. Data analysis: The evidence from meta-analyses of observational studies was graded as strong, highly suggestive, suggestive or weak according to criteria comprising the random effects estimate of meta-analyses and their largest study, the number of cases, 95% prediction intervals, I2 heterogeneity index between studies, excess significance bias, small study effect and sensitivity analysis using credibility ceilings. Interventional meta-analyses of randomised controlled trials were assessed separately based on the statistical significance of reported associations, the risk of bias and quality of evidence (GRADE) of included meta-analyses. Results A total of 117 meta-analyses of observational cohort studies and 200 meta-analyses of randomised clinical trials that evaluated 317 outcomes were included. Strong or highly suggestive evidence only supported a positive association between gestational diabetes and caesarean section, large for gestational age babies, major congenital malformations and heart defects and an inverse relationship between metformin use and ovarian cancer incidence. Only
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Maternal diet and body composition show little impact on key milk components, genetics prevailsThis study aimed to investigate the potential influence of short-term maternal diet and current body composition on human milk oligosaccharide (HMO) profiles in mature human milk. The study found a lack of clear and consistent associations between maternal nutrition and HMO concentrations in mature human milk from healthy lactating women with adequate dietary intake.
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