COVID-19 vaccination with bacterial peptide conjugated to receptor-binding domain elicits potent immune response amsterdamumc SARSCoV2 COVID19 Vaccine Vaccination
By Bhavana KunkalikarJul 6 2022Reviewed by Aimee Molineux In a recent study published in the iScience journal, researchers assessed the efficiency of immunization with a bacterial peptide conjugated to the severe acute respiratory syndrome coronavirus 2 receptor-binding domain against SARS-CoV-2 infection.
The team achieved immune recognition of SARS-CoV-2 RBD by conjugating the sequence to a chimeric designer peptide engineered by the researchers. The CDP comprises clusters of amino acids having either charged side chains or bulky hydrophilic groups, derived from three different bacterial proteins, namely ZapB which is the cell division protein, IbpA which is a small heat shock protein, and TFP . The developed conjugate protein named CPD-RBD was expressed and purified.
Results Related StoriesThe study results showed that adding the DCP component to the SARS-CoV-2 RBD increased the solubility as well as the protein yield of the resulting conjugate protein CPD-RBD. The in silico analysis of the sequence of the conjugate protein displayed the alpha-helix or beta-strand domains. Furthermore, the B-cell and T-cell epitopes observed in the in silico analysis indicated potent immune recognition.
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