Predictable mutations chart cancer’s path. Researchers from Stanford Medicine have discovered that cancer cells-to-be accumulate a series of specific genetic changes in a predictable and sequential way years before they are identifiable as pre-malignancies. Many of these changes affect pathways tha
Researchers at Stanford Medicine have found that cancer cells undergo a series of specific and predictable genetic changes years before they become pre-malignant. This study could enable earlier diagnosis and intervention, potentially stopping cancer development at its earliest stages.have discovered that cancer cells-to-be accumulate a series of specific genetic changes in a predictable and sequential way years before they are identifiable as pre-malignancies.
“Ideally, we would find ways to intercept this progression before the cells become truly cancerous,” said Christina Curtis, Ph.D., professor of medicine, genetics, and biomedical data science. “Can we identify a minimal constellation of genetic alterations that imply the cell will progress? And, if so, can we intervene? The striking reproducibility in the genetic changes we observed from multiple donors suggests it’s possible.”.
The researchers found that these early changes usually occur in biological pathways that control when and how often a cell divides, that interfere with a cell’s intricate internal signaling network coordinating the thousands of steps necessary to keep it running smoothly, or that control cell structure and polarity — its ability to know what is “up” and “down” and to situate itself with respect to neighboring cells to form a functioning tissue.
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