Omicron caused fewer cases of MIS-C in children than delta and they were milder, reports new study
In our clinical practice, we noted less severe MIS-C cases, a paucity of vaccinated admissions and a number of incidental cases of SARS-CoV-2 positivity during the Omicron wave. Only one study, which had a very limited data collection during the Omicron wave, suggested no difference in incidental versus attributable SARS-CoV-2 positivity between Delta and Omicron [].
Adjudication of each PCR-positive case to ascribe if hospitalization was due to COVID-19 or for an unrelated disorder was performed by two independent reviewers . Disagreements were reviewed by a third reviewer who served as the tiebreaker . Demographic data, presenting symptoms, findings, laboratory data, imaging, and assigned diagnoses, were tabulated. Groups were divided by causative variant as well as cases determined to be incidental, non-respiratory , or respiratory disease.
Dichotomous variables were compared with Fisher’s exact test or chi squared to determine statistical significance. Continuous variables were evaluated with Student’s-Test at 95% confidence and alpha of 0.05 to determine statistical significance. Vaccine efficacy was calculated using the formula VE=1 − ARV/ARU where ARV is the attack rate in vaccinated patients and ARU is the attack rate in unvaccinated patients [A total of 287 charts were evaluated, and 16 were omitted.
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