Dementia with Lewy bodies (DLB) is a common form of dementia that currently has no cure. Previous research has suggested that the gut microbiome, or the microorganisms that reside in the human digestive tract, may play a role in the neurodegenerative disorder Parkinson's disease. However, the specif
increases brain-derived neurotrophic factor, a key protein that supports the growth, development, and maintenance of neurons in the central and peripheral nervous systems. Therefore, its decrease in DLB is likely to be associated with cognitive decline.are intestinal bacteria that carry an enzyme, the product of which regulates inflammation in a region of the brain called the substantia nigra.
The substantia nigra produces dopamine, a neurotransmitter that is involved in the regulation of movement and is deficient in Parkinson’s disease. Compared to Parkinson’s disease, the levels of these bacteria were higher in people with DLB. This may explain why the effect on movement is delayed, a key feature that distinguishes DLB from Parkinson’s disease.
“Our findings can be used both for both diagnosis and treatment,” explains Ohno. “If a patient with Parkinson’s disease develops dementia in one year after the onset of motor symptoms, they are diagnosed with DLB. However, we cannot currently predict whether a patient with Parkinson’s disease will become a DLB patient. The gut microbiome will help to identify such patients.”in patients with Parkinson’s is expected to delay neuroinflammation in the substantia nigra,” Ohno added.
Reference: “Gut microbiota in dementia with Lewy bodies” by Hiroshi Nishiwaki, Jun Ueyama, Kenichi Kashihara, Mikako Ito, Tomonari Hamaguchi, Tetsuya Maeda, Yoshio Tsuboi, Masahisa Katsuno, Masaaki Hirayama and Kinji Ohno, 9 December 2022,
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Seattle Police recover gun and three stolen cars after arresting three peoplePolice investigated the stolen cars and detained five people.
Read more »
Bruce Willis steps out with friends after announcement of dementia diagnosisBruce Willis was seen grabbing coffee with friends, the first time he was spotted in public since the announcement of his frontotemporal dementia diagnosis.
Read more »
See the first photos of Bruce Willis since dementia diagnosisThe “Die Hard” star, 67, enjoyed a casual stroll Thursday with two friends by his side in Santa Monica, Calif., in his first sighting since the news broke.
Read more »
Israel declares Persian pottery inscription fake, debunking archaeological breakthrough discoveriesThe inscription on a Persian pottery shard bearing the name of Darius the Great was declared fake. An expert revealed that she altered the artifact at an Israeli site.
Read more »
Silver Alert activated for 79-year-old man with dementiaTexas Center for the Missing has issued a Houston Regional Silver Alert on behalf of the Harris County Precinct 4 Constables Office for 79-year-old John G. York.
Read more »
Regular laxative use correlated with higher dementia risk in U.K. studyAn analysis supports a hypothesis that laxative use may change the gut microbiome, the researchers say.
Read more »