Design of combination therapy for engineered bacterial therapeutics in non-small cell lung cancer - Scientific Reports

New bacterial therapy approach to treat lungcancer CUSEAS SciReports

to target the significantly enriched pathways in our analysis. We hypothesized—if under Stθ treatment, H1819 and H460 are dependent on the signaling through these pathways for their survival, a combinatorial strategy with each drug and Stθ would eliminate more cancer cells than the single treatments. Indeed, when combinatorically treated with each drug and Stθ, 4 out of 7 combinations showed robust efficacy across both spheroids compared to drug-only or lysate ofexpressing θ toxin.

Taking AKT signaling as an example, we observed high expression of phopho-AKT upon treatment with bacterial θ toxin and this signal was reduced in presence of MK2206 drug, which is known to block AKT-phosphorylation at Ser473. This data suggests biological changes induced by the θ toxin treatment in NSCLC cells can be exploited to design new combination therapies.

We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:

medical_xpress /  🏆 101. in UK

Australia Latest News, Australia Headlines

Similar News:You can also read news stories similar to this one that we have collected from other news sources.

This 'lightsaber' on Mars is actually a really important scientific sampleIt might look like a lightsaber from Star Wars, but it’s actually an important sample collected by Nasa’s rover 🤖
Read more »

New restaurant coming to Silverburn as boss teases 'huge changes' in New YearTHE boss of one of Scotland’s biggest shopping centres has revealed ambitious plans to diversify its range of attractions as its new owners seek…
Read more »

Boxing Day 2022 Sales: The Best Menswear DealsStart the new year with a new wardrobe
Read more »

Sheffield steel Covid memorial sculpture design revealedThe steel willow tree will be a tribute to those who died and to key workers, the council says.
Read more »

It's official: the Nintendo Switch has a major design flaw(But we already knew that.)
Read more »

Romeo Beckham unveils new neck tattoo as he follows in dad David's footstepsRomeo Beckham looks to be following in his dad David’s footsteps as he revealed his new neck tattoo on social media.
Read more »