Scientists have made a `paradigm shifting' discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer's disease and potentially Down syndrome.
Scientists at the University of Colorado Anschutz Medical Campus have made a `paradigm shifting' discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer's disease and potentially Down syndrome.For over 30 years, researchers believed that LTP or long-term potentiation, which is crucial for learning and memory, required enzymatic actions by an enzyme known as CaMKII.
That's significant, Bayer said, because it opens the door to the therapeutic use of a new class of inhibitors that target only the enzymatic activity of CaMKII, but not the structural functions required for memory and learning. The researchers found one group of inhibitors that protected from the Abeta effects without impairing LTP, making it potentially useful in treating a number of brain diseases without debilitating side effects."The implications are that a certain class of CaMKII activity inhibitors actually could be used chronically to treat brain conditions including Alzheimer's disease," said Bayer, senior author of the study.
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