Biomedical scientists have confirmed that newly discovered cells in the thymus are just like M cells, which are mostly known for their presence in the intestinal epithelium.
It came as a surprise to Professor David Lo and his graduate student Diana Del Castillo when they were recently consulted by researchers in Israel for their expertise on specialized cells called Microfold cells, or M cells, which are mostly known for their presence in the intestinal epithelium.
"I have been working on these cells for several years, so when the Israeli team contacted me, I was intrigued," Lo said."I learned this group had been doing studies on the cellular architecture of stromal cells -- cells that make up certain types of connective tissue -- in the thymus and, using a new advanced method, had discovered a population of cells much like the M cells we see in the gut and airways.
Lo explained that for many years the thymus has been a tissue of interest to immunologists because most of the immune system's development is centered and dependent on the thymus."It's still an ongoing deep puzzle that continues to attract interest," he said."The thymus offers clues to how the immune system got its start.
Del Castillo, who is working toward her doctoral degree in biomedical sciences, used genetically engineered mice to tackle the questions from the Israeli researchers. The thymus also ensures that lymphocytes do not accidentally attack our own tissues; the thymic medulla is where these decisions are made, the UCR scientists said.
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