Findings from novel analytic approach could contribute to discovery of new therapeutic targets for Alzheimer's disease. Mount Sinai researchers have published a study today (February 22, 2023) in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the ro
Scientists from Mount Sinai have provided fresh insights into the involvement of DNA methylation in Alzheimer’s disease . According to their study, DNA methylation has a significant influence on the co-expression networks of genes and proteins related to AD. Consequently, this could potentially uncover novel neuropathological processes and molecular mechanisms, ultimately resulting in the development of innovative therapeutic interventions for Alzheimer’s disease.
The study was conducted using a novel analytical approach to quantify the impact of DNA methylation on gene and protein expression and a large cohort of post-mortem control, mild cognitive impaired , and AD brains from the Mount Sinai Brain Bank.
“Our study represents the first comprehensive effort to integrate high-throughput profiling of multi-omics in Alzheimer’s disease,” said senior author, Bin Zhang, PhD, Willard T.C. Johnson Research Professor of Neurogenetics and Director of the Mount Sinai Center for Transformative Disease Modeling. “It provides a framework for future data integration at the multi-scale network level and could lead to the discovery of new targets for drug discovery in Alzheimer’s disease.
The results of this study offer a novel approach to investigating the relationship between DNA methylation and gene/protein expression, and highlight the importance of epigenetic mechanisms in human diseases such as AD. The researchers plan to extend their methods to study the methylomic variation and impacts on multiscale networks at the single-cell level, which could provide new insights into the DNA methylation profiles of individual cell types.
Reference: “Genome-wide methylomic regulation of multiscale gene networks in Alzheimer’s disease” 22 February 2023,
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