Newalgorithm can predict diabetic kidneydisease sbpdiscovery NatureComms
. The prediction model based on our multisite methylation signature also had comparable performance with established risk equations using clinical parameters to predict adverse renal outcome, whereas our data provided additional insights on biological pathways. Our results also suggest that the methylation signature could capture most of the information provided by clinical risk factors, and that inclusion of clinical risk factors did not substantially improve prediction.
Our study has several strengths, including methylation profiling of a moderately large number of subjects with type 2 diabetes with long duration of follow-up for kidney outcomes and assessment of kidney function decline. Most subjects were free of DKD at baseline. We acknowledge several limitations.
Between 1995 and December 31, 2007, a consecutive cohort consisting of 10,129 patients with diabetes was assessed, with follow-up. Clinical outcomes were defined using hospital discharge diagnoses based on the International Classification of Diseases, Ninth Revision . The Hong Kong Hospital Authority Central Computer System records admissions to all public hospitals, which provides about 95% of inpatient bed-days in Hong Kong.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing - Genome MedicineEpigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a strategy using nanopore-based single-molecule sequencing to measure cfDNA methylomes. This approach generated up to 200 million reads for a single cfDNA sample from cancer patients, an order of magnitude improvement over existing nanopore sequencing methods. We developed a single-molecule classifier to determine whether individual reads originated from a tumor or immune cells. Leveraging methylomes of matched tumors and immune cells, we characterized cfDNA methylomes of cancer patients for longitudinal monitoring during treatment.
Read more »
Tripadvisor's top 5 nature attractions and parks in HertfordshireHere we round up the top five nature attractions and parks in Hertfordshire according to Tripadvisor.
Read more »
Steeltown Murders: How a DNA-first caught a serial killer 30 years onPioneering scientific analysis found a child murderer and inspired new BBC drama Steeltown Murders.
Read more »
ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain - Nature NeuroscienceThe molecular diversity of microglia has been described. Here the authors show that ARG1-expressing microglia are enriched in phagocytic inclusions and are involved in hippocampal innervation and spine maturation in mice. ARG1-expressing microglia also modulate cognition in a sex-dependent manner.
Read more »
Six more lions speared to death by Kenyan herders just days after one of the country's oldest lions was killedResidents near Kenya's nature reserves say that lions and other animals kill livestock and domestic animals - a growing problem as humans and wildlife continue to compete for land and resources.
Read more »
Superstar triathletes join game-changing rural broadband roll out by Quickline for Yorkshire and Lincolnshire homesCelebrated triathletes the Brownlee brothers have teamed up with East Yorkshire-based broadband provider Quickline Communications to spread the word about the rollout of its fast and reliable services in rural communities
Read more »