Mice trials show that nanodevices are not harmful in large dosages The ability to create DNA structures for use in biomedical applications like creating vaccinations or medication delivery systems has been made possible by advances in nanotechnology, but a recent study in mice looks into the safet
Using DNA Origami, which involves folding complementary strands of DNA into double helixes, scientists can create small devices with intricate structures that could be injected into the body to deliver medications or do other tasks.structures for use in biomedical applications like creating vaccinations or medication delivery systems has been made possible by advances in nanotechnology, but a recent study in mice looks into the safety of the technology.
“DNA is unbelievable in terms of construction and how it’s able to be manipulated and designed to form nano-robots in a very coordinated manner,” said Christopher Lucas, lead author of the study and a research scientist in mechanical and aerospace engineering at Ohio State. “We believe this technology, which has an incredible amount of potential, can be used to diagnose, treat and prevent disease.
Researchers did see that Tri and Horse created shape-dependent inflammatory responses, but because the response diminished over time, they showed that the immune reaction was relatively harmless in the long run. “It was a modest immune response, but it wasn’t toxic to the animals,” said Lucas. “Understanding that was really key as we move towards preclinical development, and ready the technology for drug delivery applications.
But it’s hard to predict the challenges other kinds of nanostructures might run into inside a human or animal body.
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