DNA Origami Used to Create Catalog of Nanostructures DukeU ASU
By Dr. Priyom Bose, Ph.D.Jan 5 2023Reviewed by Megan Craig, M.Sc. DNA origami is a technique used for the nanoscale folding of DNA to develop two-dimensional and three-dimensional shapes at a nanoscale range.
As reported in Science Advances, researchers from Duke University and Arizona State University have focussed on improving the existing DNA design principles to overcome the past challenges concerning the shape selection, accessibility, and mechanical rigidity of the 3D DNA nanostructures. The wide-ranging applications of 3D DNA nanostructures are often restricted by the limitations associated with the existing DNA nanomolecular forms. Typically, for interdisciplinary applications, traditional techniques are used to create 3D DNA nanomaterials, where DNA helices are straight and parallel to a common vector. However, capsule-like functionality is required for optimal DNA nanostructures applications, achieved by developing rigid and hollowed DNA nanostructures.
Development of Improved 3D DNA Origami Using DNAxiS The new study focussed on improving the existing designing principle for developing enclosed, curved DNA nanostructures. It introduced a new Computer-aided design , called DNAxiS, which is the first software to automate the corresponding escalation in design tedium. This software is based on heuristic optimization algorithms.
Before the introduction of DNAixS, the short DNA strands were primarily bound in the wrong position of the longer DNA strand; as a result, incorrect DNA origami was formed. To develop a specific shaped DNA nanostructure, the software generates a list of DNA strands that can self-assemble to form the right configuration.
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