Prophylactic aflibercept does not prevent vision loss in patients with diabeticretinopathy, according to new data presented at ARVO2023 diabeteseye
are indicated for all forms of diabetic retinopathy. So researchers, led by Raj Maturi, MD, ophthalmologist at Midwest Eye Institute in Indianapolis, set out to see if early treatment could protect vision in less severe forms of diabetic retinopathy.
After 4 years of up to quarterly injections, early intervention significantly improved signs of disease progression. Patients' vision fared the same whether they received aflibercept early or once their disease progressed. The mean change in visual acuity over 4 years in aflibercept vs placebo was -2.7 vs. -2.4 letters."If you are giving [intraocular] injections to prevent something you can easily treat, what's the point?" said Nimesh Patel, MD, a retina specialist at Mass Eye and Ear in Boston, who was not involved in the study.
The anti-VEGF injections are expensive and time-intensive, requiring patients to come in frequently, according to Jampol. Plus giving the drug in the early stages of diseases, like NPDR, requires an intraocular injection into a healthy eye with good vision, Patel said, putting it at unnecessary risk for complications.Clinicians must weigh the costs and risks of a preventive treatment in people who are healthy from a vision standpoint, Patel said.
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