Early outpatient treatment of COVID-19 with metformin could reduce the risk of developing long COVID UMNews OutpatientTreatment Metformin
By Dr. Chinta SidharthanMar 9 2023Reviewed by Aimee Molineux *Important notice: Preprints with The Lancet / SSRN publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
About the study In the present study, the researchers conducted a large-scale, quadruple-blinded, randomized, placebo-controlled, phase three clinical trial that assessed the efficacy of early outpatient treatment of COVID-19 patients with fluvoxamine, ivermectin, or metformin. They conducted a 300-day follow-up to determine if the early treatment preventet PASC.
Results The findings indicated that early outpatient treatment of COVID-19 patients with metformin resulted in a relative decrease of 42% and an absolute decrease of 4.3% in the incidence of long COVID, compared to a placebo, and reduced the long COVID hazard ratio to 0.58. Treatment with ivermectin and fluvoxamine did not show similar results. Among the group treated with metformin, the incidence rate of long COVID was 6.3% as compared to the placebo group, which reported a 10.
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