Preventing dementia: Meditation still under investigation uclnews jamaneuro
Each composite subscore was computed by averaging the z scores of the scales that were assigned to the respective composite, while the global composite score corresponded to the mean of the 3 composite subscores.
Adverse events and serious adverse events were recorded throughout the study when reported by the participants and systematically at each study visit during a consultation with a physician.The trial was powered to detect a relevant effect size of 0.75 for the meditation intervention, as suggested by a meta-analysis of meditation effects on morphometric neuroimaging markers.To detect an effect size of 0.75 for each of the 4 comparisons, with 80% power and a 2-sided type I error of 1.
For the secondary outcomes, the statistical analysis plan focused on between-group differences in mean changes in the global composite score and subscores in meditation vs non-native language training so as to highlight the specific effects of meditation compared with its active control.
Analyses were performed using SAS statistical software version 9.4 for the coprimary outcomes and R version 4.0.2 for the secondary outcomes. Two-sidedvalues were statistically significant at less than .0125 for each coprimary outcome and less than .05 for secondary outcomes. Analysis took place between December 2020 and October 2021 .
Baseline characteristics of the 136 participants included in the intention-to-treat analysis are detailed in. There were no major clinical differences in any demographic or clinical characteristics between groups. The median follow-up time between pre- and postintervention visits was 21.1 months. The mean class attendance for meditation and non-native language groups was 62.0 and 57.9 of 72 classes, respectively.
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