A systematic review and meta-analysis published in Reproductive Biology and Endocrinology finds that patients with thin endometrium may face higher risks of certain adverse obstetric and neonatal outcomes. Further studies are recommended.
In addition to the above, decreased EMT may be associated with certain ART process, thus leading to higher risks. For example, a previous meta-analysis showed that artificial cycles could lead to higher HDP and PTB rate [
]. In most of included studies, the endometrial preparation protocols were significantly different between normal and thin endometrium groups. Therefore, this may lead to a difference in obstetric and neonatal outcomes.To our knowledge, this systematic review and meta-analysis is the first study to comprehensively evaluate the relationship between thin endometrium and adverse obstetric and neonatal outcomes. Of the 14 included studies, 11 were published in recent five years.
This study has some limitations. First and most importantly, all included studies are retrospective cohort studies or case–control studies with inherent bias. Analysis was based on crude data instead of adjusted data, and lack of prospective studies may lead to overestimation or underestimation of results. Secondly, due to different cut-off values of included studies, we cannot find a unified EMT to analyze.
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