The initiation of bronchodilator therapy within 30 days of diagnosis positively affects clinical outcomes in patients with chronic obstructive pulmonary disease, reports a study published in Respiratory Research.
The study protocol was approved by the NPO-MINS Institutional Review Board in 2021. The study was conducted in accordance with the Ethical Guidelines for Biomedical Research Involving Human Subjects, the ethical principles of the Declaration of Helsinki, and all relevant regulations applicable to noninterventional studies. The requirement for informed consent was waived because the available data in the RWD database were standardized and anonymized.
The study population consisted of incident patients with COPD without a prior diagnosis of COPD identified during the study period. The full analysis set included all incident patients with COPD at the index date, excluding those with an exacerbation during the grouping periods .
Incident patients with COPD meeting the eligibility criteria were categorized into the “prompt therapy” group or the “delayed therapy” group .The primary outcome was the occurrence of an exacerbation after the grouping period. The time from the day following the grouping period to the first exacerbation and the AER of incident COPD were compared between the prompt and delayed therapy groups. Exacerbations were classified as moderate or severe.
Kaplan–Meier plots for the time to first exacerbation among incident patients with COPD are presented by treatment initiation groups . The proportion of events and censoring as well as the median time to first exacerbation were based on the Kaplan–Meier method, and hazard ratios and corresponding 95% confidence intervals between groups were calculated using a Cox proportional hazards model including the treatment initiation groups.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Inhibition of Omicron BA.1 and BA.4 Variants After Fourth Vaccination or Tixagevimab and Cilgavimab AdministrationThis cohort study assesses the capacity of passive immunization and tixagevimab and cilgavimab to inhibit interaction between receptor-binding domains and angiotensin-converting enzyme 2 in patients with hemato-oncologic diseases.
Read more »
Mortality of patients with hospital-onset sepsis in hospitals with all-day and non-all-day rapid response teams: a prospective nationwide multicenter cohort study - Critical CareBackground Hospital-onset sepsis is associated with a higher in-hospital mortality rate than community-onset sepsis. Many hospitals have implemented rapid response teams (RRTs) for early detection and timely management of at-risk hospitalized patients. However, the effectiveness of an all-day RRT over a non-all-day RRT in reducing the risk of in-hospital mortality in patient with hospital-onset sepsis is unclear. We aimed to determine the effect of the RRT’s operating hours on in-hospital mortality in inpatient patients with sepsis. Methods We conducted a nationwide cohort study of adult patients with hospital-onset sepsis prospectively collected from the Korean Sepsis Alliance (KSA) Database from 16 tertiary referral or university-affiliated hospitals in South Korea between September of 2019 and February of 2020. RRT was implemented in 11 hospitals, of which 5 (45.5%) operated 24-h RRT (all-day RRT) and the remaining 6 (54.5%) had part-day RRT (non-all-day RRT). The primary outcome was in-hospital mortality between the two groups. Results Of the 405 patients with hospital-onset sepsis, 206 (50.9%) were admitted to hospitals operating all-day RRT, whereas 199 (49.1%) were hospitalized in hospitals with non-all-day RRT. A total of 73 of the 206 patients in the all-day group (35.4%) and 85 of the 199 patients in the non-all-day group (42.7%) died in the hospital (P = 0.133). After adjustments for co-variables, the implementation of all-day RRT was associated with a significant reduction in in-hospital mortality (adjusted odds ratio 0.57; 95% confidence interval 0.35–0.93; P = 0.024). Conclusions In comparison with non-all-day RRTs, the availability of all-day RRTs was associated with reduced in-hospital mortality among patients with hospital-onset sepsis.
Read more »
Modified herpes virus shows promise killing off cancer cells - with one patient seeing disease vanishPatients were injected with a drug that was a weakened form of the cold sore virus - herpes simplex - that has been modified to kill tumours. The study lead said it was rare to see such a good response at such an early stage.
Read more »