Effects of SARS-CoV-2-associated stress among pregnant women on development of fetus brain Brain SARSCoV2 Stress Coronavirus Disease COVID Neurology medrxivpreprint ChildrensLA PittTweet KeckMedUSC
By Pooja Toshniwal PahariaOct 30 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers in the United States evaluated the effects of maternal coronavirus disease 2019 pandemic-associated stress and fetal brain development using magnetic resonance imaging .
About the study The present study investigated fetal brain developmental changes associated with maternal COVID-19-associated stress using MRI. Perinatal data and demographical and self-reported survey data of the study participants were obtained from online surveys within a day before MRI imaging.
Results In total, 45 maternal-fetal pairs completed the MRI sessions. However, three were excluded due to missing postal code data, and another three were excluded since segmented images of their brain could not be obtained. As a result, the images of 39 participants were considered for modeling structural changes, and those of 43 participants were considered for modeling functional changes in the fetal brains.
No statistically significant associations were observed between the normalized volume data of other fetal brain structures and COI-SEE or COPE stress. However, a statistically significant inverse association between COPE stress and temporal variability was observed. Among coping behaviors, venting and humor were the most commonly used behaviors by less stressed participants than those who reported high stress levels.
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