Epitope mapping reveals the humoral responses against the main SARS-CoV-2 structural proteins in infected patients from Africa SciReports PasteurDakar HESAM_Univ pasteurMG epitope SARSCoV2 COVID19 coronavirus covid
By Neha MathurJan 18 2023Reviewed by Danielle Ellis, B.Sc. In a recent article published in Scientific Reports, researchers performed immunoglobulin M and IgG epitope mapping against 487 severe acute respiratory syndrome coronavirus 2 peptides. These peptides encompassed four main structural proteins of SARS-CoV-2, viz., spike glycoprotein, envelope , nucleocapsid , and membrane proteins.
The study population comprised 65 and 16 SARS-CoV-2-infected patients and 32 and 10 uninfected individuals from Senegal and Madagascar, respectively. The researchers collected serum samples from these two groups and assessed whether their varying IgM and IgG epitope distributions explained their different COVID-19 clinical profiles. Further, they compared the results with previous studies from Europe, Asia, and the United States of America .
Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Furthermore, the observed humoral responses to SARS-CoV-2 in people from Madagascar and Senegal were quite comparable, with some differences due to varying patient profiles at sampling time. Samples belonged to patients with early or late-stage SARS-CoV-2 infections.
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