Opticaltweezers untangle chemotherapy agent's impact on DNA cornell nchembio
Extended Data Fig. 7 Topo II-mediated DNA loop, sliding, and tether breakage detected by either the DNA stretching or the DNA unzipping experiment.
In a stretching experiment, if topo II traps a DNA loop , then the applied force on DNA slide topo II along the T-segment to reduce the DNA loop size, disrupt the DNA loop, and then separate the topo II dimer, leading to tether breakage. If topo II does not trap a DNA loop , then the applied force may directly separate the topo II dimer, leading to tether breakage.
Extended Data Fig. 8 Detailed analysis of topo II’s ‘burst-and-pause’ on supercoiled DNA in the presence of etoposide. Typical traces of the converted number of helical turns relaxed versus time for yeast topo II , human topo IIα , and human topo IIβ acting on supercoiled DNA under 0.2 pN in the presence of 1 mM ATP with or without etoposide. Data were smoothed with a 5-s sliding window filter. A pause-detection algorithm was used to detect pausing states .
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