Researchers demonstrate that the circadian clock aids cells in preserving and recovering their normal function during and after extended periods of starvation. According to a study recently published in eLife, cells with a functioning molecular clock are more capable of adapting to fluctuations i
Researchers demonstrate that the circadian clock aids cells in preserving and recovering their normal function during and after extended periods of starvation., cells with a functioning molecular clock are more capable of adapting to fluctuations in glucose supply and recover quicker from prolonged starvation.
Circadian clocks are closely linked to metabolism: on the one hand, the clock rhythmically modulates many metabolic pathways, and on the other, nutrients and metabolic cues influence the clock’s function. This is achieved through finely tuned feedback loops, where some positive components of the clock activate others, and these then negatively feedback the original activating components.
Usually, hyperphosphorylation prevents FRQ from inhibiting WCC activity – so the authors speculated that the higher activity might speed up the degradation of the WCC. When they looked at the downstream actions of WCC, there was little difference between the starved cells and those still growing in glucose. Together, this suggests that the circadian clock was still functioning robustly and driving the rhythmic expression of cellular genes during glucose starvation.
Next, the team looked at whether having a functional clock was important for cells to recover after glucose starvation. They found that the growth ofcells lacking a functional FRQ or WCC was significantly slower than that of normal cells when glucose was added, implying that a functional clock supports the cells’ regeneration.
Australia Latest News, Australia Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
The Case of the Incredibly Long-Lived Mouse CellsScientists kept the rodents’ immune T cells active four times longer than mice can live—with huge implications for cancer, vaccination, and aging research.
Read more »
Researchers Provide New Insight Into the Carefully Choreographed Dance of Nerve and Vascular CellsRecent research conducted by the Universities of Bonn and Heidelberg sheds light on a carefully choreographed dance. Nerve cells require vast amounts of energy and oxygen which they receive through the bloodstream. This results in nerve tissue being densely intertwined with numerous blood vessels.
Read more »
Scientists Create Semi-Living 'Cyborg' Cells That Could Transform MedicineThrough a complex chemical process, scientists have been able to develop versatile, synthetic 'cyborg' cells in the lab.
Read more »
How genetically engineered immune cells are beating some cancersIn some cases, it is now possible to genetically engineer the immune system to banish cancers like T-cell leukaemia that were previously unresponsive to treatments
Read more »
Semi-living 'cyborg cells' could treat cancer, suggests new studyAccording to the University of California, Davis researchers, cyborg cells may serve as environmental and health instruments.
Read more »
Even Kim Kardashian loves these $12 makeup remover wipesThe drugstore beauty buy has a 5-star Amazon rating — and recommendations from Ariana Grande, Khloé Kardashian and Lucy Hale.
Read more »