Changes in skull and brain size, as well as the thickness of the cortex, across individuals born between the years 1930 and 1970.
By Dr. Liji Thomas, MDMar 27 2024Reviewed by Lily Ramsey, LLM The development and upkeep of the human brain are influenced by both genetic factors and environmental conditions, which may subsequently impact the risk of dementia later in life. Thus, a recent study published in JAMA Neurology assessed whether there were changes in skull and brain size, as well as the thickness of the cortex, across individuals born between the years 1930 and 1970.
The Framingham Heart Study cohort includes many generations of people, followed up over decades. The difference between the earliest and latest subjects to be enrolled in the cohort spans over 80 years. What were the findings? There were over 3,200 participants, the mean age at MRI being 58 years. The images revealed that multiple brain volume measurements showed an upward trajectory with the later birth cohorts.
Regional measures also varied with the birth cohort, showing a definite trend. Both HV and WMV went up with the decade of birth. So did the CSA, while the cortical thickness decreased, implying cortical atrophy.
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