An experimental prostate cancer therapy may change the way patients are treated for the second-deadliest cancer in men
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In a"landmark" phase III clinical trial, presented at the European Society of Medical Oncology conference in Barcelona on Monday, the drug olaparib was shown to be safe and effective in delaying the progression of disease in men with both metastatic castrate-resistant prostate cancer and mutations in their homologous recombination repair, or HRR, genes.
Cancer: The facts 01:00This research comparing olaparib vs. enzalutamide or abiraterone has been called the PROfound study."PROfound is a landmark trial for patients with advanced prostate cancer who have progressed after hormonal therapy. Lynparza will be not only a much needed practice-changing therapy but is the first to unveil the promise of targeted therapies against genomic alterations in this disease," Dr.
"These findings suggest that olaparib may be beneficial in the treatment of patients with metastatic hormone-resistant prostate cancer and a mutation in DNA repair genes -- especially BRCA or ATM mutations," Mahal said. "So the question now would be, how much would this medication olaparib apply for patients with other mutations?" he said."The evidence appears to be convincing for the BRCA1, BRCA2 and ATM mutations.
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