Many children with acute lymphoblastic leukemia (ALL) have a good outcome of their disease. After two years of chemotherapy treatment, 9 out of 10 children are cured. But some children have a more aggressive form of the disease. For example, children with a so-called Ikaros change in the DNA of their leukemia cells have a greater risk of their disease coming back after treatment. In order to improve the chances of survival and quality of life of all children with leukemia, the treatment protocol has been continuously adapted over the years, based on the latest scientific insights.
at the Princess Máxima Center for pediatric oncology in the Netherlands, will present the outcomes of the ALL-11 treatment protocol at the annual conference of the American Society of Hematology . The Dutch researchers looked at the benefit of an adapted treatment in specific groups of children with
Analysis of data from all children with ALL, regardless of subtype, showed that the five-year survival rate has improved stepwise over the past 30 years from 80% to 94% under the ALL-11 protocol., doctors and researchers also looked at the benefit of a less intensive treatment plan for three groups of children. This included children with a DNA change in their leukemia cells linked to a very high chance of recovery, and children with Down syndrome who experience more severe side effects.
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