Moderna and Pfizer are testing mRNA flu shots that target the strains most likely to circulate during the 2022 flu season
as being most likely to circulate during the 2022-2023 flu season in the northern hemisphere. The early studies from both Pfizer and Moderna showed the mRNA flu vaccine was safe, which led to the ongoing late-stage studies that will focus more specifically on demonstrating whether the shots are effective at protecting people from influenza. Current vaccines, which use decades-old technology that involves growing the influenza virus in chicken eggs, have traditionally been moderately effective.
mRNA vaccines should eliminate this mismatch. Because the technology is more flexible, manufacturers can create shots with new genetic sequences in about three months or so. That means that if a bad mismatch occurs during a flu season, scientists could potentially produce a new batch of mRNA flu vaccines targeting the right genetic sequences during the same seasonThat, in turn, could reduce the hospitalizations and deaths caused by influenza, which still remain relatively high.
While an mRNA flu shot would be a huge advance in vaccine technology, there may be other ways to protect people from respiratory illness with combination shots. In a separate trial, Moderna is also investigating combination vaccines that would immunize people against both SARS-CoV-2 and influenza in a single shot.
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